CISH anticorps (N-Term)

N° du produit ABIN928660

Cet anticorps Lapin Polyclonal détecte spécifiquement CISH dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CISH anticorps (N-Term) (ABIN928660)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CISH anticorps

Épitope: N-Term

Réactivité croisée: Souris

Purification: Purified

Immunogène: Cish antibody was raised in rabbit using the N terminal of Cish as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

Cish Blocking Peptide, (ABIN5612894), is also available for use as a blocking control in assays to test for specificity of this Cish antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: Cish

Sujet: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Synonyms: Polyclonal Cish antibody, Anti-Cish antibody, cytokine inducible SH2-containing protein antibody, AI385595 antibody, CIS1 antibody, Cis antibody, F17 antibody, F23 antibody.

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus