Caspase 1 anticorps (Middle Region)

N° du produit ABIN929105

L’anticorps anti-Caspase 1 Polyclonal Lapin est utilisé pour la détection de Caspase 1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Caspase 1 anticorps (Middle Region) (ABIN929105)

Antigène: Caspase 1 (CASP1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Caspase 1 anticorps

Épitope: Middle Region

Purification: Purified

Immunogène: CASP1 antibody was raised in rabbit using the middle region of CASP1 as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

CASP1 Blocking Peptide, ABIN5612630, is also available for use as a blocking control in assays to test for specificity of this CASP1 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur Caspase 1

Antigène: Caspase 1 (CASP1)

Autre désignation: CASP1

Sujet: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. Synonyms: Polyclonal CASP1 antibody, Anti-CASP1 antibody, caspase 1, apoptosis-related cysteine peptidase, interleukin 1, beta, convertase antibody, ICE antibody, IL1BC antibody, P45 antibody.

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome