AP2A2 anticorps (C-Term)

N° du produit ABIN929411

L’anticorps Lapin Polyclonal anti-AP2A2 a été validé pour WB. Il convient pour détecter AP2A2 dans des échantillons de Humain.

Aperçu rapide pour AP2A2 anticorps (C-Term) (ABIN929411)

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AP2A2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AP2A2 anticorps

Épitope: C-Term

Purification: Purified

Immunogène: AP2 A2 antibody was raised in rabbit using the C terminal of AP2 2 as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

AP2A2 Blocking Peptide, (ABIN5612096), is also available for use as a blocking control in assays to test for specificity of this AP2A2 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur AP2A2

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Autre désignation: AP2A2

Sujet: AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. Synonyms: Polyclonal AP2A2 antibody, Anti-AP2A2 antibody, adaptor-related protein complex 2, alpha 2 subunit antibody, ADTAB antibody, CLAPA2 antibody, HIP9 antibody, HYPJ antibody.

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome