XBP1 anticorps

N° du produit ABIN930955

Détail du produit anti-XBP1 anticorps

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Dot Blot (DB)

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogène: XBP1 antibody was raised in mouse using recombinant X-Box Binding Protein 1

Clone: XBP1H6E5

Isotype: IgG1

Information d'application

Indications d'application: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: XBP1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1 (XBP1 Produits)

Synonymes: anticorps treb5, anticorps xXBP1, anticorps xbp2, anticorps XBP1P1, anticorps XBPP1, anticorps xbp1, anticorps TREB5, anticorps XBP-1, anticorps XBP2, anticorps D11Ertd39e, anticorps TREB-5, anticorps HTF, anticorps cb918, anticorps id:ibd1195, anticorps trebf, anticorps wu:fb02h05, anticorps wu:fb63f10, anticorps xbp1a, anticorps xbp1b, anticorps X-box binding protein 1, anticorps X-box binding protein 1 L homeolog, anticorps xbp1, anticorps XBP1, anticorps Xbp1, anticorps xbp1.L

Sujet: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. Synonyms: Monoclonal XBP1 antibody, Anti-XBP1 antibody, Xbox binding protein 1 antibody, XBP2 antibody, TREB5 antibody.

Pathways: ER-Nucleus Signaling, Unfolded Protein Response