Ret Proto-Oncogene anticorps (AA 896-1063)

N° du produit ABIN931456

Cet anticorps Souris Monoclonal détecte spécifiquement Ret Proto-Oncogene dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Ret Proto-Oncogene anticorps (AA 896-1063) (ABIN931456)

Antigène: Ret Proto-Oncogene (RET)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ret Proto-Oncogene est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 8D10C9

Détail du produit anti-Ret Proto-Oncogene anticorps

Épitope: AA 896-1063

Immunogène: Ret antibody was raised in Mouse using a purified recombinant fragment of Ret(aa896-1063) expressed in E. coli as the immunogen.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Détails sur Ret Proto-Oncogene

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: Ret

Sujet: Ret is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity. Synonyms: Monoclonal Ret antibody, Anti-Ret antibody, c-Ret antibody, Ret proto-oncogene antibody.

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation