CD44 anticorps (Biotin)

N° du produit ABIN94124

L’anticorps Souris Monoclonal anti-CD44 a été validé pour FACS, WB, ELISA et IP. Il convient pour détecter CD44 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour CD44 anticorps (Biotin) (ABIN94124)

Antigène: CD44

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD44 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Clone: MEM-85

Détail du produit anti-CD44 anticorps (Biotin)

Fonction: Anti-Hu CD44 Biotin

Specificité: The antibody MEM-85 reacts with an extracellular antigen of both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.), it is negative on platelets and hepatocytes.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogène: Leukocytes of a patient suffering from LGL Type Leukaemia.

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-3 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.
Avoid prolonged exposure to light.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD44 (Biotin) (ABIN94124)

Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." dans: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

Bazil, Strominger: "Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 3, pp. 1314-22, (1994) (PubMed).

Stefanová, Hilgert, Bazil, Kristofová, Horejsí: "Human leucocyte surface glycoprotein CDw44 and lymphocyte homing receptor are identical molecules." dans: Immunogenetics, Vol. 29, Issue 6, pp. 402-4, (1989) (PubMed).

Détails sur CD44

Antigène: CD44

Autre désignation: CD44

Sujet: CD44 Molecule,CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.,PGP-I, HUTCH-I, ECMR-III, Hermes antigen, Hyaluronate receptor, Heparan sulfate proteoglycan, Epican, MC56, MIC4, INLU, LHR

ID gène: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling