CDK1 anticorps

N° du produit ABIN94446

Cet anticorps anti-CDK1 est un anticorps Souris Monoclonal détectant CDK1 dans WB, IP, IHC (p) et ICC. Adapté pour Humain, Boeuf (Vache) et Non-Human Primate. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour CDK1 anticorps (ABIN94446)

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Reactivité: Humain, Boeuf (Vache), Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: POH-1

Détail du produit anti-CDK1 anticorps

Fonction: Anti-CDK1 Purified

Specificité: The antibody POH-1 specifically detects Cdk1 (p34Cdc2, an intracellular antigen). Staining of Cdk1 reflects the proliferating potential of respective tissue.

Aucune reactivité croisée: Drosophila melanogaster, Souris, Rat, Xenopus laevis

Réactivité croisée (Details): Human, Non-Human Primates, Bovine

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Bacterially expressed full-length human Cdk1 protein

Isotype: IgG2a

Information d'application

Indications d'application: Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: thymus.
Western blotting: Recommended dilution: 1-2 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CDK1 (ABIN94446)

Lukás, Draetta, Bartek: "Distinct forms of human CDC2 identified by novel monoclonal antibodies." dans: European journal of biochemistry / FEBS, Vol. 207, Issue 1, pp. 169-76, (1992) (PubMed).

Détails sur CDK1

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Autre désignation: CDK1

Sujet: Cyclin dependent kinase 1,Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. Cdk1 also contributes to the control of DNA replication. Cdk1 can be ihibited by several transcriptional targets of p53, such as p21WAF.,p34Cdc2, p34 protein kinase, CDK1, CDC2, CDC28A

ID gène: 983

UniProt: B7Z3D6

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA