SOCS3 anticorps

N° du produit ABIN94467

Cet anticorps anti-SOCS3 est un anticorps Souris Monoclonal détectant SOCS3 dans WB. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour SOCS3 anticorps (ABIN94467)

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB)

Clone: SO1

Détail du produit anti-SOCS3 anticorps

Fonction: Anti-SOCS3 Purified

Specificité: The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Full-length SOCS3 protein.

Isotype: IgG2b

Information d'application

Indications d'application: Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-SOCS3 (ABIN94467)

Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." dans: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, (2007) (PubMed).

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3

Sujet: Suppressor of cytokine signaling 3,SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.,SOCS-3, CIS3, SSI3

ID gène: 9021

UniProt: Q6FI39

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C