BCL3 anticorps

N° du produit ABIN950631

Cet anticorps anti-BCL3 est un anticorps Hamster Monoclonal détectant BCL3 dans WB, FACS et EIA. Adapté pour Humain et Souris.

Aperçu rapide pour BCL3 anticorps (ABIN950631)

Antigène: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Reactivité: Humain, Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: Ham150-3-5

Détail du produit anti-BCL3 anticorps

Specificité: Recognizes B-cell Leukemia/lymphoma 3

Réactivité croisée (Details): Species reactivity (tested):Human and Mouse.

Purification: Protein G Affinity Chromatography.

Immunogène: Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BCL3

Antigène: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Autre désignation: Bcl-3

Sujet: B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80 % homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.Synonyms: B-cell lymphoma 3-encoded protein, BCL3, BCL4, D19S37

ID gène: 602

NCBI Accession: NP_005169

UniProt: P20749

Pathways: Signalisation NF-kappaB, Maintenance of Protein Location, Protein targeting to Nucleus