Cullin 1 anticorps (C-Term)

N° du produit ABIN951732

Détail du produit anti-Cullin 1 anticorps

Antigène: Cullin 1 (CUL1)

Épitope: AA 679-708, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to CUL1.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 679-708 amino acids from the C-terminal region of human CUL1

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Cullin 1

Antigène: Cullin 1 (CUL1)

Autre désignation: Cullin 1 (CUL1 Produits)

Synonymes: anticorps LOC100282292, anticorps Cullin-1, anticorps Cul1, anticorps zgc:55747, anticorps zgc:77500, anticorps wu:fc13a10, anticorps cullin-1, anticorps ATCUL1, anticorps AUXIN RESISTANT 6, anticorps AXR6, anticorps T10P11.26, anticorps T10P11_26, anticorps cullin 1, anticorps cul1, anticorps wu:fi43h07, anticorps wu:fj43a08, anticorps zgc:111899, anticorps zgc:55483, anticorps Cul-1, anticorps cullin 1, anticorps cullin-1, anticorps Cullin 1, anticorps Cullin-1, anticorps cullin 1a, anticorps cullin 1 S homeolog, anticorps cullin 1b, anticorps CUL1, anticorps LOC100282292, anticorps cul1, anticorps ATEG_00491, anticorps EDI_072700, anticorps EDI_264400, anticorps SJAG_02591, anticorps BDBG_03785, anticorps Cul1, anticorps cul1a, anticorps cul1.S, anticorps cul-1, anticorps cul1b

Sujet: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquination of ORC1L, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22', the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).Synonyms: CUL-1, CUL1, Cullin-1

Poids moléculaire: 89679 Da

ID gène: 8454

NCBI Accession: NP_003583

Pathways: Cycle Cellulaire, Signalisation Hedgehog, Mitotic G1-G1/S Phases, Regulation of Cell Size