MRPS12 anticorps (Middle Region)

N° du produit ABIN953516

L’anticorps anti-MRPS12 Polyclonal Lapin est utilisé pour la détection de MRPS12 dans des échantillons de Humain. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour MRPS12 anticorps (Middle Region) (ABIN953516)

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRPS12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-MRPS12 anticorps

Épitope: AA 35-67, Middle Region

Specificité: This antibody recognizes Human MRPS12 (Center).

Purification: Affinity Chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 35-67 amino acids from the Central region of Human MRPS12 Genename: MRPS12

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MRPS12

Antigène: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Autre désignation: MRPS12

Sujet: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same proteinSynonyms: 28S ribosomal protein S12, MRP-S12, MT-RPS12, RPMS12, RPSM12, S12mt, mitochondrial

ID gène: 6183

NCBI Accession: NP_066930

Pathways: Sensory Perception of Sound