CCL2 anticorps
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- Antigène Voir toutes CCL2 Anticorps
- CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
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Reactivité
- Humain, Souris, Chien, Porc, Boeuf (Vache), Cat, Orang-Utan
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CCL2 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- This product was Protein-A purified from monospecific antiserum by chromatography. This antibody is specific for bovine CCL2 protein. A BLAST analysis was used to suggest cross-reactivity with CCL2 from bovine sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against Bos mutus (wild yak) CCL2 (100%), Bubalus bubalis (water buffalo) CCL2 (99%), Bos indicus (zebu) CCL2 (99%), Sus scrofa (85%), Bos Taurus (81%), swine (98%), human and cat (90%), orangutan and dog (89%) and mouse (90%). Cross-reactivity with CCL2 from other sources has not been determined.
- Réactivité croisée
- Porc, Humain, Chat, Orang-Utan, Chien, Souris
- Attributs du produit
- CCL2 is a small cytokine belonging to the CC chemokine family that recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing a signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a total molecular weight of approximately 8.8 kDa. The cell surface receptors that bind CCL2 are CCR2 and CCR4. CCL2 is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor kappaB (NFkappaB). In human osteoclasts, CCL2 and RANTES (regulated on activation normal T cell expressed and secreted) may act as an autocrine loop in human osteoclast differentiation. CCL2 causes the degranulation of basophils and mast cells, an effect potentiated by pre-treatment with IL-3 and other cytokines.
- Stérilité
- Sterile filtered
- Immunogène
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This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein raised in yeast, corresponding to the 76 amino acids of the mature bovine CCL2 protein.
Immunogen Type: RecombinantProtein - Isotype
- IgG
- Top Product
- Discover our top product CCL2 Anticorps primaire
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- Indications d'application
- This protein-A purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 8.8 kDa in size corresponding to bovine CCL2 protein by western blotting in the appropriate cell lysate or extract.
- Commentaires
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Gene Name: CCL2
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
- Concentration
- 1.0 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- Date de péremption
- 12 months
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- Antigène
- CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
- Autre désignation
- CCL2 (CCL2 Produits)
- Synonymes
- anticorps GDCF-2, anticorps HC11, anticorps HSMCR30, anticorps MCAF, anticorps MCP-1, anticorps MCP1, anticorps SCYA2, anticorps SMC-CF, anticorps AI323594, anticorps JE, anticorps Scya2, anticorps Sigje, anticorps MCP-1A, anticorps MCP1A, anticorps C-C motif chemokine ligand 2, anticorps chemokine (C-C motif) ligand 2, anticorps C-C motif chemokine 2, anticorps CCL2, anticorps Ccl2, anticorps LOC101120093
- Sujet
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CCL2 is a small cytokine belonging to the CC chemokine family that recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing a signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a total molecular weight of approximately 8.8 kDa. The cell surface receptors that bind CCL2 are CCR2 and CCR4. CCL2 is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor κB (NFκB). In human osteoclasts, CCL2 and RANTES (regulated on activation normal T cell expressed and secreted) may act as an autocrine loop in human osteoclast differentiation. CCL2 causes the degranulation of basophils and mast cells, an effect potentiated by pre-treatment with IL-3 and other cytokines.
Synonyms: Chemokine (C-C motif) ligand 2, monocyte chemotactic (or chemoattractant) protein-1 (MCP-1) - ID gène
- 281043, 27806711
- UniProt
- A5PJF7
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2
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