alpha 2 Macroglobulin anticorps (C-Term)

N° du produit ABIN965492

L’anticorps Lapin Polyclonal anti-alpha 2 Macroglobulin a été validé pour IHC. Il convient pour détecter alpha 2 Macroglobulin dans des échantillons de Humain et Rat. Il y a 5+ publications disponibles.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (C-Term) (ABIN965492)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-alpha 2 Macroglobulin anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human A2M (Alpha-2-macroglobulin precursor)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-alpha 2 Macroglobulin (ABIN965492)

Zhang, Li, Martin, Aebersold: "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." dans: Nature biotechnology, Vol. 21, Issue 6, pp. 660-6, (2003) (PubMed).

Matthijs, Devriendt, Cassiman, Van den Berghe, Marynen: "Structure of the human alpha-2 macroglobulin gene and its promotor." dans: Biochemical and biophysical research communications, Vol. 184, Issue 2, pp. 596-603, (1992) (PubMed).

Bishop, Bell: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." dans: Cell, Vol. 42, Issue 1, pp. 51-60, (1985) (PubMed).

Sottrup-Jensen, Stepanik, Kristensen, Wierzbicki, Jones, Lønblad, Magnusson, Petersen: "Primary structure of human alpha 2-macroglobulin. V. The complete structure." dans: The Journal of biological chemistry, Vol. 259, Issue 13, pp. 8318-27, (1984) (PubMed).

Sottrup-Jensen, Lønblad, Stepanik, Petersen, Magnusson, Jörnvall: "Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex." dans: FEBS letters, Vol. 127, Issue 2, pp. 167-73, (1981) (PubMed).

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: A2M

Sujet: A2M (Alpha-2-macroglobulin) is able to inhibit all four classes of proteinases by a unique `trapping' mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Pathways: Lipid Metabolism