alpha 2 Macroglobulin anticorps (C-Term)

N° du produit ABIN965492

Détail du produit anti-alpha 2 Macroglobulin anticorps

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Épitope: C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human A2M (Alpha-2-macroglobulin precursor)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-alpha 2 Macroglobulin (ABIN965492)

Zhang, Li, Martin, Aebersold: "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." dans: Nature biotechnology, Vol. 21, Issue 6, pp. 660-6, (2003) (PubMed).

Matthijs, Devriendt, Cassiman, Van den Berghe, Marynen: "Structure of the human alpha-2 macroglobulin gene and its promotor." dans: Biochemical and biophysical research communications, Vol. 184, Issue 2, pp. 596-603, (1992) (PubMed).

Bishop, Bell: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." dans: Cell, Vol. 42, Issue 1, pp. 51-60, (1985) (PubMed).

Sottrup-Jensen, Stepanik, Kristensen, Wierzbicki, Jones, Lønblad, Magnusson, Petersen: "Primary structure of human alpha 2-macroglobulin. V. The complete structure." dans: The Journal of biological chemistry, Vol. 259, Issue 13, pp. 8318-27, (1984) (PubMed).

Sottrup-Jensen, Lønblad, Stepanik, Petersen, Magnusson, Jörnvall: "Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex." dans: FEBS letters, Vol. 127, Issue 2, pp. 167-73, (1981) (PubMed).

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: A2M (A2M Produits)

Synonymes: anticorps A2MD, anticorps CPAMD5, anticorps FWP007, anticorps S863-7, anticorps A2MAC1, anticorps A2m1, anticorps A2maa, anticorps Mam, anticorps A2mp, anticorps A2M, anticorps LOC733429, anticorps endod, anticorps cpamd5, anticorps fwp007, anticorps s863-7, anticorps a2mb, anticorps endodermin, anticorps Alpha-2-M, anticorps alpha-2-macroglobulin, anticorps pregnancy-zone protein L homeolog, anticorps alpha-2-macroglobulin S homeolog, anticorps pregnancy zone protein, anticorps alpha-2-macroglobulin-like, anticorps A2M, anticorps A2m, anticorps LOC477699, anticorps pzp.L, anticorps AZL_c00450, anticorps LOC100349077, anticorps a2m, anticorps LOC100061656, anticorps LOC100090399, anticorps a2m.S, anticorps LOC100469973, anticorps LOC100595735, anticorps PZP, anticorps LOC100353095, anticorps LOC101122940, anticorps LOC101801552, anticorps LOC100911545

Sujet: A2M (Alpha-2-macroglobulin) is able to inhibit all four classes of proteinases by a unique `trapping' mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Pathways: Lipid Metabolism