ABI1 anticorps (C-Term)

N° du produit ABIN965496

Cet anticorps anti-ABI1 est un anticorps Lapin Polyclonal détectant ABI1 dans IHC. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour ABI1 anticorps (C-Term) (ABIN965496)

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABI1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-ABI1 anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ABI1 (Abl-interactor 1)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ABI1 (ABIN965496)

Yamamoto, Suzuki, Sakaki: "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease." dans: Gene, Vol. 271, Issue 2, pp. 159-69, (2001) (PubMed).

Fan, Goff: "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases." dans: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7591-601, (2000) (PubMed).

Ziemnicka-Kotula, Xu, Gu, Potempska, Kim, Jenkins, Trenkner, Kotula: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." dans: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, (1998) (PubMed).

Taki, Shibuya, Taniwaki, Hanada, Morishita, Bessho, Yanagisawa, Hayashi: "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)." dans: Blood, Vol. 92, Issue 4, pp. 1125-30, (1998) (PubMed).

Biesova, Piccoli, Wong: "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth." dans: Oncogene, Vol. 14, Issue 2, pp. 233-41, (1997) (PubMed).

Détails sur ABI1

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Autre désignation: ABI1

Sujet: The ABI1 (Abl-interactor 1) may act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/ or ABL2. The ABI1 may play a role in regulation of EGF-induced Erk pathway activation. It is involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 It participates in transduction of signals from Ras to Rac.

Pathways: Signalisation RTK, Response to Water Deprivation, ER-Nucleus Signaling