APOB anticorps

N° du produit ABIN965573

1 publication est disponible pour ce produit. L’anticorps anti-APOB Monoclonal produit chez le Souris a été validé pour WB, ELISA, FACS et IF. Il convient pour la détection de APOB dans des échantillons provenant de Humain. }

Aperçu rapide pour APOB anticorps (ABIN965573)

Antigène: APOB (Apolipoprotein B (APOB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOB est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 6G6

Détail du produit anti-APOB anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ApoB expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-APOB (ABIN965573)

Peterson, Mack, Hall, Alsup, Alexander, Sully, Sawires, Cheung, Otto, Gresham: "Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection." dans: Cell host & microbe, Vol. 4, Issue 6, pp. 555-66, (2008) (PubMed).

Détails sur APOB

Antigène: APOB (Apolipoprotein B (APOB))

Autre désignation: ApoB

Sujet: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
Synonyms: FLDB, LDLCQ4

Poids moléculaire: 516kDa

ID gène: 338

Pathways: Lipid Metabolism