Aurora Kinase B anticorps

N° du produit ABIN965626

Cet anticorps Monoclonal détecte spécifiquement Aurora Kinase B dans WB et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour Aurora Kinase B anticorps (ABIN965626)

Antigène: Aurora Kinase B (AURKB)

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora Kinase B est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Aurora Kinase B anticorps

Specificité: Ni-NTA purified truncated recombinant AURKB expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-Aurora Kinase B (ABIN965626)

Song, So, Cheng, Tang, Croft: "Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion." dans: Immunity, Vol. 22, Issue 5, pp. 621-31, (2005) (PubMed).

Kapoor, Lavoie, Frappier: "EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases." dans: Molecular and cellular biology, Vol. 25, Issue 12, pp. 4934-45, (2005) (PubMed).

Détails sur Aurora Kinase B

Antigène: Aurora Kinase B (AURKB)

Autre désignation: AURKB

Sujet: AURKB (aurora kinase B, AIK2 or aurora-B), with 344amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis. It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases

ID gène: 9212

Pathways: TCR Signaling, Cycle Cellulaire, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades