c-FOS anticorps (Middle Region)

N° du produit ABIN965712

Détail du produit anti-c-FOS anticorps

Antigène: c-FOS (c-Fos) (c-Fos)

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-FOS est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Proto-oncogene c-Fos (FOS) detection. Tested with WB in Human, Mouse, Rat.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human C-FOS, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Références pour anticorps anti-c-FOS (ABIN965712)

Grigoriadis, Wang, Wagner: "Fos and bone cell development: lessons from a nuclear oncogene." dans: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, (1996) (PubMed).

Saez, Rutberg, Mueller, Oppenheim, Smoluk, Yuspa, Spiegelman: "c-fos is required for malignant progression of skin tumors." dans: Cell, Vol. 82, Issue 5, pp. 721-32, (1995) (PubMed).

Barker, Rabin, Watson, Breg, Ruddle, Verma: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, (1984) (PubMed).

Détails sur c-FOS

Antigène: c-FOS (c-Fos) (c-Fos)

Autre désignation: Proto-oncogene c-Fos (c-Fos Produits)

Synonymes: anticorps AP-1, anticorps C-FOS, anticorps p55, anticorps c-fos, anticorps D12Rfj1, anticorps cFos, anticorps cFOS, anticorps fos, anticorps Fos proto-oncogene, AP-1 transcription factor subunit, anticorps FBJ osteosarcoma oncogene, anticorps proto-oncogene c-Fos-like, anticorps FOS, anticorps Fos, anticorps LOC101078177

Sujet: The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Pathways: S100 Proteins