CDK9 anticorps

N° du produit ABIN965846

L’anticorps Souris Monoclonal anti-CDK9 a été validé pour WB, ELISA et IHC. Il convient pour détecter CDK9 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour CDK9 anticorps (ABIN965846)

Antigène: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK9 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 1B5D10

Détail du produit anti-CDK9 anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CDK9 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-CDK9 (ABIN965846)

Montanuy, Torremocha, Hernández-Munain, Suñé: "Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9." dans: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7368-78, (2008) (PubMed).

Sabò, Lusic, Cereseto, Giacca: "Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription." dans: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2201-12, (2008) (PubMed).

Détails sur CDK9

Antigène: CDK9 (Cyclin-Dependent Kinase 9 (CDK9))

Autre désignation: CDK9

Sujet: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Tissue specificity: Ubiquitous.
Synonyms: TAK, C-2k, CTK1, CDC2L4, PITALRE

Poids moléculaire: 43kDa

ID gène: 1025

Pathways: Cycle Cellulaire