DERL1 anticorps (N-Term)

N° du produit ABIN965990

L’anticorps Lapin Polyclonal anti-DERL1 a été validé pour IHC. Il convient pour détecter DERL1 dans des échantillons de Humain et Souris.

Aperçu rapide pour DERL1 anticorps (N-Term) (ABIN965990)

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DERL1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-DERL1 anticorps

Épitope: N-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL1 (Derlin-1)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur DERL1

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Autre désignation: DERL1

Sujet: DERL1 (Derlin-1) is specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. DERL1 (Derlin-1) aarticipates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. DERL1 may act by forming a channel that allows the retro-translocation of misfolded proteins into the cytosol and transfer them to the ATPase VCP complex, which translocates and ubiquitinates misfolded proteins. In case of infection by the cytomegalovirus, it plays a central role in the export from the ER and subsequent degredation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. DERL1 (Derlin-1) interacts with VIMP/SELS and indirectly with VCP, suggesting that it forms a membrane complex with VIMP that serves as a receptor for VCP.

Pathways: ER-Nucleus Signaling