ELK1 anticorps

N° du produit ABIN966064

Détail du produit anti-ELK1 anticorps

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp ELK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: Ni-NTA purified truncated recombinant ELK1 expressed in E. Coli strain BL21 (DE3).

Purification: Ascites.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-ELK1 (ABIN966064)

Hsieh, Wu, Tsai, Huang, Hsieh, Liu: "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells." dans: Biochemical and biophysical research communications, Vol. 339, Issue 1, pp. 217-25, (2005) (PubMed).

Gille, Strahl, Shaw: "Activation of ternary complex factor Elk-1 by stress-activated protein kinases." dans: Current biology : CB, Vol. 5, Issue 10, pp. 1191-200, (1996) (PubMed).

Gille, Kortenjann, Thomae, Moomaw, Slaughter, Cobb, Shaw: "ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation." dans: The EMBO journal, Vol. 14, Issue 5, pp. 951-62, (1995) (PubMed).

Rao, Huebner, Isobe, ar-Rushdi, Croce, Reddy: "elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints." dans: Science (New York, N.Y.), Vol. 244, Issue 4900, pp. 66-70, (1989) (PubMed).

Détails sur ELK1

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Autre désignation: ELK1 (ELK1 Produits)

Sujet: The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

ID gène: 2002

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling