ErbB2/Her2 anticorps

N° du produit ABIN966279

Cet anticorps anti-ErbB2/Her2 est un anticorps Lapin Polyclonal détectant ErbB2/Her2 dans IHC. Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 6+ publications.

Aperçu rapide pour ErbB2/Her2 anticorps (ABIN966279)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-ErbB2/Her2 anticorps

Specificité: HER2 (Ab-877) antibody detects endogenous levels of total HER2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 877 (T-E-YP-H-A).

Information d'application

Indications d'application: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ErbB2/Her2 (ABIN966279)

Dittadi, Gion: "More about: prognostic importance of low c-erbB2 expression in breast tumors." dans: Journal of the National Cancer Institute, Vol. 92, Issue 17, pp. 1443-4, (2000) (PubMed).

Muthuswamy, Gilman, Brugge: "Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers." dans: Molecular and cellular biology, Vol. 19, Issue 10, pp. 6845-57, (2000) (PubMed).

Zhang, Wong-Riley: "Synthesis and degradation of cytochrome oxidase subunit mRNAs in neurons: differential bigenomic regulation by neuronal activity." dans: Journal of neuroscience research, Vol. 60, Issue 3, pp. 338-44, (2000) (PubMed).

Klapper, Waterman, Sela, Yarden: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." dans: Cancer research, Vol. 60, Issue 13, pp. 3384-8, (2000) (PubMed).

Kwon, Bhattacharyya, Alberta, Giannobile, Cheon, Stiles, Pomeroy: "Activation of ErbB2 during wallerian degeneration of sciatic nerve." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 17, Issue 21, pp. 8293-9, (1997) (PubMed).

Qian, LeVea, Freeman, Dougall, Greene: "Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 4, pp. 1500-4, (1994) (PubMed).

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: HER2

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development