IGF1 anticorps (AA 80-96)

N° du produit ABIN966342

Cité dans 2 publications. Cet anticorps anti-IGF1 Polyclonal (ABIN966342) détecte spécifiquement IGF1 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour IGF1 anticorps (AA 80-96) (ABIN966342)

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Reactivité: Humain, Rat

Hôte: Veuillez nous consulter SVP

Clonalité: Polyclonal

Conjugué: Cet anticorp IGF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IGF1 anticorps

Épitope: AA 80-96

Immunogène: A synthetic peptide corresponding to a sequence at the middle region of human IGF-1 (80-96 aa), different from the mouse and rat sequence by one amino acid.

Information d'application

Indications d'application: WB: The detection limit for IGF-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Stock: -20 °C

Références pour anticorps anti-IGF1 (ABIN966342)

Höppener, de Pagter-Holthuizen, Geurts van Kessel, Jansen, Kittur, Antonarakis, Lips, Sussenbach: "The human gene encoding insulin-like growth factor I is located on chromosome 12." dans: Human genetics, Vol. 69, Issue 2, pp. 157-60, (1985) (PubMed).

Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: "Sequence of cDNA encoding human insulin-like growth factor I precursor." dans: Nature, Vol. 306, Issue 5943, pp. 609-11, (1984) (PubMed).

Détails sur IGF1

Antigène: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Autre désignation: IGF-1

Sujet: Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.

Pathways: Signalisation RTK, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation