NOX3 anticorps (C-Term)

N° du produit ABIN966688

Cet anticorps Lapin Polyclonal détecte spécifiquement NOX3 dans IHC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 3+ publications.

Aperçu rapide pour NOX3 anticorps (C-Term) (ABIN966688)

Antigène: NOX3 (NADPH Oxidase 3 (NOX3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOX3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-NOX3 anticorps

Épitope: C-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NOX3(NADPH oxidase 3)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-NOX3 (ABIN966688)

Ueno, Takeya, Miyano, Kikuchi, Sumimoto: "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators." dans: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 23328-39, (2005) (PubMed).

Cheng, Ritsick, Lambeth: "Nox3 regulation by NOXO1, p47phox, and p67phox." dans: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34250-5, (2004) (PubMed).

Cheng, Cao, Xu, van Meir, Lambeth: "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5." dans: Gene, Vol. 269, Issue 1-2, pp. 131-40, (2001) (PubMed).

Détails sur NOX3

Antigène: NOX3 (NADPH Oxidase 3 (NOX3))

Autre désignation: NOX3

Sujet: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. NOX3(NADPH oxidase 3) plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. NOX3(NADPH oxidase 3) is activated by the ototoxic drug cisplatin and by NOXO1. NOX3 is cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. It is inhibited by diphenyleneiodonium chloride and interacts with and stabilizes CYBA/p22phox. NOX3 is expressed in fetal kidney and to a lower extent in liver, lung and spleen.
Synonyms: MOX2