NPM1 anticorps

N° du produit ABIN966704

L’anticorps Souris Monoclonal anti-NPM1 a été validé pour WB, IHC, IF et ELISA. Il convient pour détecter NPM1 dans des échantillons de Humain et Singe. Il y a 2+ publications disponibles.

Aperçu rapide pour NPM1 anticorps (ABIN966704)

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Clone: 7H10B9

Détail du produit anti-NPM1 anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NPM expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-NPM1 (ABIN966704)

Yoneda-Kato, Look, Kirstein, Valentine, Raimondi, Cohen, Carroll, Morris: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." dans: Oncogene, Vol. 12, Issue 2, pp. 265-75, (1996) (PubMed).

Morris, Kirstein, Valentine, Dittmer, Shapiro, Saltman, Look: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." dans: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, (1994) (PubMed).

Détails sur NPM1

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Autre désignation: Nucleophosmin

Sujet: Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms: B23, NPM

Poids moléculaire: 33kDa

ID gène: 4869

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly