Calreticulin anticorps (CALR)

Details for Product anti-CALR Antibody No. ABIN966933, Fournisseur: Connectez-vous pour afficher
Antigène
  • CRT
  • RO
  • SSA
  • cC1qR
  • crc
  • crt
  • Calregulin
  • CG9429
  • Clr
  • Dmel\\CG9429
  • anon-EST:Liang-2.11
  • anon-EST:Liang-2.17
  • anon-EST:fe3D7
  • clone 2.11
  • clone 2.17
  • eth
  • potp
  • cc1qr
  • ssa
  • NV19007
  • CRP55
  • ERp60
  • HACBP
  • calrl2
  • fc66d10
  • wu:fc66d10
  • wu:fj50c03
  • zgc:66153
  • calreticulin
  • calreticulin L homeolog
  • Calreticulin
  • putative calreticulin
  • CALR
  • calr.L
  • Crt
  • crt
  • CRT
  • Calr
  • calr
  • LMJF_31_2600
  • Crc
  • LOC8269812
Reactivité
Humain
320
176
129
59
57
56
53
52
52
50
43
43
8
6
4
3
2
1
1
1
1
1
Hôte
Lapin
233
72
22
5
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Calreticulin est non-conjugé
19
18
16
9
8
7
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), ELISA
293
181
142
99
75
71
59
59
34
13
7
5
4
3
2
1
1
1
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Synthetic peptide corresponding to aa(E-E-E-D-V-P-G-Q-A-K-D-E-L-C)of human Calreticulin, conjugated to KLH.
Isotype IgG2a
Purification Rabbit anti-serum.
Plasmids, Primers & others Plasmids, Primers & others Calreticulin products on genomics-online (e.g. as negative or positive controls)
Autre désignation Calreticulin (CALR Antibody Extrait)
Sujet Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNAbinding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
Synonyms: RO, CRT, SSA, cC1qR, FLJ26680, CALR
ID gène 811
Pathways Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded protein response
Indications d'application Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Stock 4 °C
Background publications Harada, Okiyoneda, Hashimoto, Ueno, Nakamura, Yamahira, Sugahara, Shuto, Wada, Suico, Kai: "Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator." dans: The Journal of biological chemistry, Vol. 281, Issue 18, pp. 12841-8, 2006 (PubMed).

Tan, Chen, Li, Mabuchi, Bouvier: "The calcium- and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain." dans: Biochimica et biophysica acta, Vol. 1760, Issue 5, pp. 745-53, 2006 (PubMed).

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