RRM2B anticorps (Ribonucleotide Reductase M2 B (TP53 Inducible)) (N-Term)

Details for Product anti-RRM2B Antibody No. ABIN966974, Fournisseur: Connectez-vous pour afficher
Antigène
  • p53r2
  • RRM2B
  • MTDPS8A
  • MTDPS8B
  • P53R2
  • p53R2
  • ribonucleotide reductase M2 B (TP53 inducible) S homeolog
  • ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • ribonucleotide reductase M2 B (TP53 inducible)
  • rrm2b.S
  • RRM2B
  • rrm2b
  • Rrm2b
Épitope
N-Term
12
12
11
11
9
9
7
4
2
2
2
2
1
1
1
Reactivité
Humain, Souris
94
45
43
4
3
3
2
2
2
2
1
1
1
1
1
1
Hôte
Lapin
88
6
Clonalité
Polyclonal
Conjugué
Cet anticorp RRM2B est non-conjugé
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
76
42
17
14
13
9
4
2
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)
Plasmids, Primers & others Plasmids, Primers & others RRM2B products on genomics-online (e.g. as negative or positive controls)
Autre désignation RRM2B (RRM2B Antibody Extrait)
Sujet RRM2B (Ribonucleoside-diphosphate reductase subunit M2B) plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. RRM2B supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. RRM2B contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. RRM2B binds 2 iron ions per subunit. RRM2B interacts with p53/TP53 and interacts with RRM1 in response to DNA damage. RRM2B is widely expressed at a high level in skeletal muscle and at a weak level in thymus. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT)
Synonyms: P53R2( p53-inducible ribonucleotide reductase small subunit 2-like protein)
Pathways Signalisation p53, Negative Regulation of intrinsic apoptotic Signaling
Restrictions For Research Use only
Background publications Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: "The full-ORF clone resource of the German cDNA Consortium." dans: BMC genomics, Vol. 8, pp. 399, 2008 (PubMed).

Tanaka, Arakawa, Yamaguchi, Shiraishi, Fukuda, Matsui, Takei, Nakamura: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." dans: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000 (PubMed).

Produit citée dans: Xue, Zhou, Liu, Qiu, Jin, Yen: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." dans: Cancer research, Vol. 63, Issue 5, pp. 980-6, 2003 (PubMed).

Guittet, Håkansson, Voevodskaya, Fridd, Gräslund, Arakawa, Nakamura, Thelander: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, 2001 (PubMed).

Yamaguchi, Matsuda, Sagiya, Iwadate, Fujino, Nakamura, Arakawa: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." dans: Cancer research, Vol. 61, Issue 22, pp. 8256-62, 2001 (PubMed).

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