s100b anticorps (S100 Calcium Binding Protein B)

Details for Product anti-S100B Antibody No. ABIN966987, Fournisseur: Connectez-vous pour afficher
Antigène
  • NEF
  • S100
  • S100-B
  • S100beta
  • S100P
  • AI850290
  • Bpb
  • si:dkey-110p14.2
  • wu:fq18b10
  • zgc:92776
  • S100 calcium binding protein B
  • S100 protein, beta polypeptide, neural
  • S100 calcium binding protein, beta (neural)
  • S100B
  • S100b
  • s100b
Reactivité
Humain
556
371
320
305
67
51
7
2
2
1
1
1
1
1
Hôte
Souris
386
209
11
5
3
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp s100b est non-conjugé
45
32
22
19
18
14
12
11
10
10
10
10
10
10
10
10
9
7
7
6
5
5
5
5
5
5
5
5
5
5
5
5
5
4
3
3
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
473
319
304
253
235
176
113
63
28
24
13
9
6
5
4
3
2
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of S100B expressed in E. Coli.
Clone 9A11B9
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others s100b products on genomics-online (e.g. as negative or positive controls)
Autre désignation S100B (S100B Antibody Extrait)
Sujet S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S100B are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin B is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Synonyms: NEF, S100, S100beta
ID gène 6285
Pathways Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Zimmer, Chaplin, Baldwin, Rast: "S100-mediated signal transduction in the nervous system and neurological diseases." dans: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 51, Issue 2, pp. 201-14, 2005 (PubMed).

Shapiro, Marks, Whitaker-Azmitia: "Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome." dans: Brain research, Vol. 1010, Issue 1-2, pp. 17-21, 2004 (PubMed).

Produit citée dans: Sorci, Riuzzi, Arcuri, Giambanco, Donato: "Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding." dans: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4880-94, 2004 (PubMed).

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