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SOCS2 anticorps (C-Term)

SOCS2 Reactivité: Humain, Rat WB Polyclonal unconjugated
N° du produit ABIN967065
  • Antigène Voir toutes SOCS2 Anticorps
    SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
    Épitope
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 181-198, C-Term
    Reactivité
    • 43
    • 20
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    Veuillez nous consulter SVP
    Clonalité
    • 35
    • 11
    Polyclonal
    Conjugué
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp SOCS2 est non-conjugé
    Application
    • 20
    • 14
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminal of human SOCS2 (181-198 aa), identical to the related mouse and rat sequence.
    Top Product
    Discover our top product SOCS2 Anticorps primaire
  • Restrictions
    For Research Use only
  • Reconstitution
    0.2ml of distilled water will yield a concentration of 500µg/ml.
    Buffer
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Stock
    -20 °C
  • Greenhalgh, Bertolino, Asa, Metcalf, Corbin, Adams, Davey, Nicola, Hilton, Alexander: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." dans: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, (2002) (PubMed).

    Dey, Spence, Nissley, Furlanetto: "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." dans: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24095-101, (1998) (PubMed).

    Masuhara, Sakamoto, Matsumoto, Suzuki, Yasukawa, Mitsui, Wakioka, Tanimura, Sasaki, Misawa, Yokouchi, Ohtsubo, Yoshimura: "Cloning and characterization of novel CIS family genes." dans: Biochemical and biophysical research communications, Vol. 239, Issue 2, pp. 439-46, (1997) (PubMed).

    Minamoto, Ikegame, Ueno, Narazaki, Naka, Yamamoto, Matsumoto, Saito, Hosoe, Kishimoto: "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." dans: Biochemical and biophysical research communications, Vol. 237, Issue 1, pp. 79-83, (1997) (PubMed).

  • Antigène
    SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
    Autre désignation
    SOCS2 (SOCS2 Produits)
    Synonymes
    anticorps CIS2, anticorps Cish2, anticorps SOCS-2, anticorps SSI-2, anticorps SSI2, anticorps STATI2, anticorps Cish1, anticorps Socs-1, anticorps Socs-2, anticorps si:dkey-202b22.1, anticorps socs2, anticorps cis2, anticorps ssi2, anticorps cish2, anticorps ssi-2, anticorps socs-2, anticorps stati2, anticorps 8030460M17, anticorps AI527257, anticorps AW108012, anticorps D130043N08Rik, anticorps JAB, anticorps hg, anticorps Cradd, anticorps Socs2, anticorps suppressor of cytokine signaling 2, anticorps suppressor of cytokine signaling 1, anticorps death domain-containing protein CRADD, anticorps suppressor of cytokine signaling 2 S homeolog, anticorps SOCS2, anticorps Socs1, anticorps Socs2, anticorps socs2, anticorps LOC100716104, anticorps socs2.S
    Sujet
    Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
    Pathways
    Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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