TDG anticorps (C-Term)

N° du produit ABIN967162

Cet anticorps Lapin Polyclonal détecte spécifiquement TDG dans IHC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 4+ publications.

Aperçu rapide pour TDG anticorps (C-Term) (ABIN967162)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-TDG anticorps

Épitope: C-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human TDG (G/T mismatch-specific thymine DNA glycosylase)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-TDG (ABIN967162)

Baba, Maita, Jee, Uchimura, Saitoh, Sugasawa, Hanaoka, Tochio, Hiroaki, Shirakawa: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." dans: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).

Hardeland, Steinacher, Jiricny, Schär: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." dans: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).

Neddermann, Gallinari, Lettieri, Schmid, Truong, Hsuan, Wiebauer, Jiricny: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." dans: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).

Neddermann, Jiricny: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG

Sujet: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. TDG(G/T mismatch-specific thymine DNA glycosylase) corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, TDG can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. TDG can also remove uracil and 5-bromouracil from mispairs with guanine. Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. TDG belongs to the TDG/mug DNA glycosylase family.

Pathways: Réparation de l'ADN, Chromatin Binding