TEK anticorps (Extracellular Domain)
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- Antigène Voir toutes TEK Anticorps
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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Épitope
- Extracellular Domain
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TEK est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Marque
- BD Pharmingen™
- Réactivité croisée
- Souris
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human TIE2 extracellular domain Recombinant Protein
- Clone
- 33
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TEK Anticorps primaire
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- Commentaires
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Related Products: ABIN967389, ABIN968537
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." dans: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, (1999) (PubMed).
: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." dans: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, (1998) (PubMed).
: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." dans: Circulation research, Vol. 81, Issue 4, pp. 567-74, (1997) (PubMed).
: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." dans: Genes & development, Vol. 8, Issue 16, pp. 1897-909, (1994) (PubMed).
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Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." dans: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, (1999) (PubMed).
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- Antigène
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- Autre désignation
- TIE2 (TEK Produits)
- Synonymes
- anticorps TEK, anticorps DKFZp469E064, anticorps AA517024, anticorps Cd202b, anticorps Hyk, anticorps Tie2, anticorps tie-2, anticorps CD202B, anticorps TIE-2, anticorps TIE2, anticorps VMCM, anticorps VMCM1, anticorps Tie-2, anticorps tie2, anticorps TEK receptor tyrosine kinase, anticorps angiopoietin-1 receptor, anticorps TEK tyrosine kinase, endothelial, anticorps TEK, anticorps LOC100408334, anticorps tek, anticorps Tek
- Sujet
- The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.
- Poids moléculaire
- 130-165 kDa
- Pathways
- Signalisation RTK, Growth Factor Binding
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