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TEK anticorps (Extracellular Domain)

TEK Reactivité: Humain, Souris WB, IHC (fro) Hôte: Souris Monoclonal 33 unconjugated
N° du produit ABIN967565
  • Antigène Voir toutes TEK Anticorps
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Épitope
    • 20
    • 19
    • 16
    • 11
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivité
    • 144
    • 74
    • 49
    • 22
    • 4
    • 3
    Humain, Souris
    Hôte
    • 128
    • 25
    • 6
    • 3
    • 2
    Souris
    Clonalité
    • 134
    • 30
    Monoclonal
    Conjugué
    • 71
    • 12
    • 9
    • 8
    • 8
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TEK est non-conjugé
    Application
    • 81
    • 60
    • 40
    • 40
    • 38
    • 33
    • 14
    • 13
    • 12
    • 8
    • 8
    • 8
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Marque
    BD Pharmingen™
     Réactivité croisée
    Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human TIE2 extracellular domain Recombinant Protein
    Clone
    33
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TEK Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968537

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." dans: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, (1999) (PubMed).

    Peters, Coogan, Berry, Marks, Iglehart, Kontos, Rao, Sankar, Trogan: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." dans: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, (1998) (PubMed).

    Wong, Haroon, Werner, Dewhirst, Greenberg, Peters: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." dans: Circulation research, Vol. 81, Issue 4, pp. 567-74, (1997) (PubMed).

    Dumont, Gradwohl, Fong, Puri, Gertsenstein, Auerbach, Breitman: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." dans: Genes & development, Vol. 8, Issue 16, pp. 1897-909, (1994) (PubMed).

  • Antigène
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Autre désignation
    TIE2 (TEK Produits)
    Synonymes
    anticorps TEK, anticorps DKFZp469E064, anticorps AA517024, anticorps Cd202b, anticorps Hyk, anticorps Tie2, anticorps tie-2, anticorps CD202B, anticorps TIE-2, anticorps TIE2, anticorps VMCM, anticorps VMCM1, anticorps Tie-2, anticorps tie2, anticorps TEK receptor tyrosine kinase, anticorps angiopoietin-1 receptor, anticorps TEK tyrosine kinase, endothelial, anticorps TEK, anticorps LOC100408334, anticorps tek, anticorps Tek
    Sujet
    The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.
    Poids moléculaire
    130-165 kDa
    Pathways
    Signalisation RTK, Growth Factor Binding
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