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Cortactin anticorps

CTTN Reactivité: Humain, Chien WB, IF, IP, IHC (f) Hôte: Souris Monoclonal 30-Cortactin unconjugated
N° du produit ABIN967709
  • Antigène Voir toutes Cortactin (CTTN) Anticorps
    Cortactin (CTTN)
    Reactivité
    • 123
    • 60
    • 43
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Chien
    Hôte
    • 123
    • 6
    • 1
    Souris
    Clonalité
    • 113
    • 17
    Monoclonal
    Conjugué
    • 73
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cortactin est non-conjugé
    Application
    • 95
    • 52
    • 51
    • 15
    • 15
    • 14
    • 14
    • 12
    • 10
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
     Réactivité croisée
    Humain, Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Chicken Cortactin
    Clone
    30-Cortactin
    Isotype
    IgG1
    Top Product
    Discover our top product CTTN Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Lavoie, Champagne, Gingras, Robert: "Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases." dans: The Journal of cell biology, Vol. 150, Issue 5, pp. 1037-56, (2000) (PubMed).

    Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." dans: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

    Dehio, Prévost, Sansonetti: "Invasion of epithelial cells by Shigella flexneri induces tyrosine phosphorylation of cortactin by a pp60c-src-mediated signalling pathway." dans: The EMBO journal, Vol. 14, Issue 11, pp. 2471-82, (1995) (PubMed).

    Wu, Parsons: "Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex." dans: The Journal of cell biology, Vol. 120, Issue 6, pp. 1417-26, (1993) (PubMed).

    Wu, Reynolds, Kanner, Vines, Parsons: "Identification and characterization of a novel cytoskeleton-associated pp60src substrate." dans: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5113-24, (1991) (PubMed).

  • Antigène
    Cortactin (CTTN)
    Autre désignation
    Cortactin (CTTN Produits)
    Synonymes
    anticorps EMS1, anticorps 1110020L01Rik, anticorps Ems1, anticorps Cttnb, anticorps CG3637, anticorps Dmel\CG3637, anticorps cortactin, anticorps cttn, anticorps CTTN1, anticorps P85.25, anticorps Cttn, anticorps ems1, anticorps CTTN, anticorps cortactin, anticorps CG3637 gene product from transcript CG3637-RD, anticorps cortactin S homeolog, anticorps cortactin L homeolog, anticorps src substrate cortactin, anticorps Src substrate cortactin, anticorps CTTN, anticorps Cttn, anticorps Cortactin, anticorps cttn.S, anticorps cttn.L, anticorps cttn, anticorps CpipJ_CPIJ006351, anticorps Bm1_57220, anticorps LOC100533277
    Sujet
    Cortactin is a protein which is represented by two structurally related isoforms of 80 kDa and 85 kDa. Sequence analysis of this protein reveals the presence of a carboxy-terminal SH3 domain, as well as six internal tandem repeats of a 37 amino acid sequence. It is able to bind to F-actin via this N-terminal repeat region, and colocalizes with actin in the cell. Cortactin was originally described as a protein that is tyrosine-phosphorylated in cells transformed by the src oncogene, in which it localizes to rosettes or podosomes. It has since been shown that other stimuli, such as bacterial invasion, treatment with growth factors, and integrin-mediated cell adhesion, are also capable of inducing phosphorylation of cortactin. Some additional evidence indicates that cortactin may actually be a substrate of syk, with src acting as an upstream signaling molecule. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    85/80 kDa
    Pathways
    Signalisation MAPK
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