Caspase 2 anticorps (AA 225-401)

N° du produit ABIN968323

Cet anticorps Souris Monoclonal détecte spécifiquement Caspase 2 dans WB et IF. Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour Caspase 2 anticorps (AA 225-401) (ABIN968323)

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 35-Caspase-2-ICH

Détail du produit anti-Caspase 2 anticorps

Épitope: AA 225-401

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human ICH-1L aa. 225-401

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Caspase 2 (ABIN968323)

Guo, Srinivasula, Druilhe, Fernandes-Alnemri, Alnemri: "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria." dans: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13430-7, (2002) (PubMed).

Li, Chen, Sinogeeva, Gorospe, Wersto, Chrest, Barnes, Liu: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." dans: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, (2002) (PubMed).

Mancini, Machamer, Roy, Nicholson, Thornberry, Casciola-Rosen, Rosen: "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis." dans: The Journal of cell biology, Vol. 149, Issue 3, pp. 603-12, (2000) (PubMed).

Shibata, Hisahara, Hara, Yamawaki, Fukuuchi, Yuan, Okano, Miura: "Caspases determine the vulnerability of oligodendrocytes in the ischemic brain." dans: The Journal of clinical investigation, Vol. 106, Issue 5, pp. 643-53, (2000) (PubMed).

Wang, Miura, Bergeron, Zhu, Yuan: "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death." dans: Cell, Vol. 78, Issue 5, pp. 739-50, (1994) (PubMed).

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: Caspase-2

Sujet: Caspase-2/ICH-1 is related to the C. elegans cell death gene product CED-3 and its mammalian homologue interleukin-1beta-converting enzyme (ICE). Caspase-2 /ICH-1 was identified from a mouse cDNA library and originally termed NEDD-2. The NEDD-2 mRNA was found to be expressed during early mouse embryonic brain development and subsequently down-regulated in adult neuronal tissue. With the identification of the human NEDD-2 gene, the murine gene was renamed Ich-1 to symbolize Ice and ced-3 homology. Caspase-2/ICH-1 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as Caspase-2 long, or ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named Caspase-2 short, or ICH-1S. Overexpression of ICH-1L induces apoptosis, while over-expression of Ich-1S suppresses Rat-1 cell death induced by serum deprivation. Thus, it appears that Caspase-2/ICH-1 plays an important dual role in programmed cell death.
Synonyms: ICH-1L

Poids moléculaire: 48 kDa

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway