Aurora Kinase B anticorps (AA 2-124)

N° du produit ABIN968357

L’anticorps Souris Monoclonal anti-Aurora Kinase B a été validé pour WB et IF. Il convient pour détecter Aurora Kinase B dans des échantillons de Humain, Souris et Rat. Il y a 5+ publications disponibles.

Aperçu rapide pour Aurora Kinase B anticorps (AA 2-124) (ABIN968357)

Antigène: Aurora Kinase B (AURKB)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora Kinase B est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 6-AIM

Détail du produit anti-Aurora Kinase B anticorps

Épitope: AA 2-124

Réactivité croisée: Humain, Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Rat AIM-1 aa. 2-124

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968537

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Aurora Kinase B (ABIN968357)

Trinkle-Mulcahy, Andrews, Wickramasinghe, Sleeman, Prescott, Lam, Lyon, Swedlow, Lamond: "Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle." dans: Molecular biology of the cell, Vol. 14, Issue 1, pp. 107-17, (2003) (PubMed).

Chen, Jin, Tahir, Zhang, Liu, Sarthy, McGonigal, Liu, Rosenberg, Ng: "Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells." dans: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 486-90, (2002) (PubMed).

Lange, Rebollo, Herold, González: "Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes." dans: The EMBO journal, Vol. 21, Issue 20, pp. 5364-74, (2002) (PubMed).

Tatsuka, Katayama, Ota, Tanaka, Odashima, Suzuki, Terada: "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells." dans: Cancer research, Vol. 58, Issue 21, pp. 4811-6, (1998) (PubMed).

Terada, Tatsuka, Suzuki, Yasuda, Fujita, Otsu: "AIM-1: a mammalian midbody-associated protein required for cytokinesis." dans: The EMBO journal, Vol. 17, Issue 3, pp. 667-76, (1998) (PubMed).

Détails sur Aurora Kinase B

Antigène: Aurora Kinase B (AURKB)

Autre désignation: AIM-1

Sujet: The mitotic phase of the cell cycle is a complex process that ensures the fidelity of chromosome segregation. During the final stage of mitosis (telophase), segregated chromosomes become less condense and nuclear membranes surround the two sets of daughter chromosomes. Simultaneously, the separation and segregation of the cytoplasm (cytokinesis) ensures complete division and formation of two identical daughter cells. Regulation of cytokinesis is poorly understood and errors in this process can lead to cell death or oncogenesis. The Drosophila serine/threonine protein kinase Aurora and the S. cerevisiae Ipl1 kinase are highly homologous and are required for progression through mitosis. Their mammalian homolog AIM-1 (also known as Aurora and Ipl1-like midbody associated protein) accumulates at the G2/M interface. During late anaphase, AIM-1 is found at the equator of central spindles. However, during telophase and cytokinesis, it is found at the midbody. Although over-expression of a kinase-inactive AIM-1 mutant disrupts formation of the cleavage furrow, nuclear division is unaffected. Thus, it is thought that AIM-1 is essential for cleavage furrowing and the onset of cytokinesis.
Synonyms: Aurora B, Aurora and Ipl1-like midbody associated protein

Poids moléculaire: 41 kDa

Pathways: TCR Signaling, Cycle Cellulaire, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades