Sortilin 1 anticorps (AA 300-422)

N° du produit ABIN968738

L’anticorps Souris Monoclonal anti-Sortilin 1 a été validé pour WB et IF. Il convient pour détecter Sortilin 1 dans des échantillons de Humain, Rat, Souris, Chien et Poulet. Il y a 3+ publications disponibles.

Aperçu rapide pour Sortilin 1 anticorps (AA 300-422) (ABIN968738)

Antigène: Sortilin 1 (SORT1)

Reactivité: Humain, Rat, Souris, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Sortilin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 48-Neurotensin Receptor 3

Détail du produit anti-Sortilin 1 anticorps

Épitope: AA 300-422

Réactivité croisée: Souris, Rat (Rattus), Chien, Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Neurotensin Receptor 3 aa. 300-422

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968700, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Sortilin 1 (ABIN968738)

Nielsen, Jacobsen, Olivecrona, Gliemann, Petersen: "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase." dans: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8832-6, (1999) (PubMed).

Mazella, Zsürger, Navarro, Chabry, Kaghad, Caput, Ferrara, Vita, Gully, Maffrand, Vincent: "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor." dans: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26273-6, (1998) (PubMed).

Morris, Ross, Lane, Moestrup, Petersen, Keller, Lienhard: "Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes." dans: The Journal of biological chemistry, Vol. 273, Issue 6, pp. 3582-7, (1998) (PubMed).

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: Neurotensin Receptor 3

Sujet: Neurotensin (NT) is a neuropeptide that modulates dopaminergic transmission, triggers analgesic responses, induces hypotension, decreases gastric acid secretion, and activates lipid digestion. NT is a ligand for NT receptors, which include both G-protein coupled and non-G-protein coupled receptors. Neurotensin Receptor 3 (NTR3) is a non-G-protein coupled receptor that has a lumenal domain homologous to sorting proteins, and a short cytoplasmic tail homologous to mannose-6-phosphate/IGF-II receptor. NTR3 was also identified as sortilin/gp95, a component of GLUT4 vesicles in adipocytes that has been implicated in lipoprotein lipase degradation. NTR3 mRNA is expressed in brain, skeletal muscle, heart, and adipocytes. NTR3 mature protein has 44 N-terminal amino acid residues cleaved off, which may facilitate ligand binding to the receptor. Cellular localization of NTR3 is in the Golgi compartment and vesicles, as well as on the cell surface. In addition to roles in neuropeptide and lipoprotein degradation, NTR3 may also be involved in receptor protein sorting. Thus, NTR3 is a multifunctional transmembrane protein that acts as both a intracellular sorting receptor and extracellular ligand-binding receptor.
Synonyms: NTR3

Poids moléculaire: 95 kDa

Pathways: Neurotrophin Signaling Pathway