Transferrin Receptor anticorps (AA 517- 623)
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- Antigène Voir toutes Transferrin Receptor (TFRC) Anticorps
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Épitope
- AA 517- 623
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Transferrin Receptor est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human Transferrin Receptor aa. 517- 623
- Clone
- 2-Transferrin
- Isotype
- IgG1
- Top Product
- Discover our top product TFRC Anticorps primaire
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- Commentaires
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Related Products: ABIN968537, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA." dans: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29400-6, (1996) (PubMed).
: "The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence." dans: Cell, Vol. 39, Issue 2 Pt 1, pp. 267-74, (1985) (PubMed).
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Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA." dans: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29400-6, (1996) (PubMed).
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- Antigène
- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
- Autre désignation
- Transferrin Receptor (TFRC Produits)
- Synonymes
- anticorps Trfr, anticorps LOC100219280, anticorps tfr, anticorps cd71, anticorps tfr1, anticorps trfr, anticorps CD71, anticorps T9, anticorps TFR, anticorps TFR1, anticorps TR, anticorps TRFR, anticorps p90, anticorps 2610028K12Rik, anticorps AI195355, anticorps AI426448, anticorps AU015758, anticorps E430033M20Rik, anticorps Mtvr-1, anticorps Mtvr1, anticorps transferrin receptor, anticorps TFRC, anticorps Tfrc, anticorps tfrc
- Sujet
- Iron acquisition is a prerequisite for cell proliferation. The transferrin receptor is the primary mode of iron uptake. This receptor mediates iron uptake through internalization and recycling of the iron carrying serum protein transferrin. Binding of transferrin to its receptor causes rapid internalization into an acidic intracellular compartment where iron dissociates from transferrin. Both the receptor and transferrin are then recycled through the exocytic pathway. The transferrin receptor is expressed in most cells and tissues, especially proliferating cells, and the receptor is expressed as a dimer of identical intergral membrane proteins. Transferrin receptor mRNA expression is inversely proportional to iron availability, and this regulation occurs through post-transcriptional control of mRNA stability. Transferrin receptor mRNA contains iron responsive elements (IRE) that are bound by IRE-binding proteins (IRP). The RNA binding of IRPs is dependent on iron levels. Thus, iron deprivation leads to increased RNA binding, which masks the recognition site of endonucleases and stabilizes transferrin receptor mRNA. This antibody is routinely tested by western blot analysis.
- Poids moléculaire
- 85 kDa
- Pathways
- Transition Metal Ion Homeostasis
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