ARPC3 anticorps (AA 10-118)

N° du produit ABIN968781

Cité dans 2 publications. Cet anticorps anti-ARPC3 Monoclonal Souris (Clone 26-p21) (ABIN968781) détecte spécifiquement ARPC3 dans WB et IF. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien et Poulet.

Aperçu rapide pour ARPC3 anticorps (AA 10-118) (ABIN968781)

Antigène: ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ARPC3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 26-p21

Détail du produit anti-ARPC3 anticorps

Épitope: AA 10-118

Réactivité croisée: Souris, Rat (Rattus), Poulet, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human p21-Arc aa. 10-118

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-ARPC3 (ABIN968781)

Zhao, Yang, Qian, Zhu: "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." dans: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, (2001) (PubMed).

Welch, DePace, Verma, Iwamatsu, Mitchison: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." dans: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, (1997) (PubMed).

Détails sur ARPC3

Antigène: ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))

Autre désignation: p21-Arc

Sujet: Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.

Poids moléculaire: 21 kDa

Pathways: Signalisation RTK, Regulation of Actin Filament Polymerization