RIPK2 anticorps (AA 333-532)

N° du produit ABIN968828

L’anticorps Souris Monoclonal anti-RIPK2 a été validé pour WB et IF. Il convient pour détecter RIPK2 dans des échantillons de Humain, Rat et Chien. Il y a 2+ publications disponibles.

Aperçu rapide pour RIPK2 anticorps (AA 333-532) (ABIN968828)

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Reactivité: Humain, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RIPK2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 25-RIG

Détail du produit anti-RIPK2 anticorps

Épitope: AA 333-532

Réactivité croisée: Chien, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human RIP2/RICK aa. 333-532

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-RIPK2 (ABIN968828)

Inohara, Koseki, Lin, del Peso, Lucas, Chen, Ogura, Núñez: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." dans: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, (2000) (PubMed).

Navas, Baldwin, Stewart: "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase." dans: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33684-90, (1999) (PubMed).

Détails sur RIPK2

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Autre désignation: RIP2/RICK

Sujet: Members of the TNFR family (TNFRs, DRs, Fas, lymphotoxin-beta-receptor, CD40, CD30, and OX-40) regulate a variety of cellular responses, such as cell activation, proliferation, differentiation, NF-kappaB activation, and apoptosis. Signaling through TNFR family members involves several families of receptor-associated proteins. RIP and RIP2 (RICK/Cardiak) are ser/thr kinase adaptor molecules that associate with TNFR complexes. Both RIPs contain homologous N-teriminal ser/thr kinase domains, but RIP contains a C-terminal death domain, while RIP2 contains a C-terminal caspase activation and recruitment domain (CARD) similar to those found in IAPs. Both RIP and RIP2 can activate NF-kappaB and cause cell death. RIP2 is recruited to TNFRs through interactions with TRAF1, TRAF5, and TRAF6, and RIP2 activation of NF-kappaB requires IKKalpha, IKKbeta, and IKKgamma. In addition, RIP2 can be activated through interactions with Ras-activated Raf1, and RIP2 can activate ERK1 and ERK2. Thus, RIP proteins may regulate TNFR signaling through both ser/thr kinase activity and interaction with the apoptotic machinery.

Poids moléculaire: 61 kDa

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades