MAP1B anticorps (AA 1745-1858)

N° du produit ABIN968911

Cet anticorps Souris Monoclonal détecte spécifiquement MAP1B dans WB. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour MAP1B anticorps (AA 1745-1858) (ABIN968911)

Antigène: MAP1B (Microtubule-Associated Protein 1B (MAP1B))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP1B est non-conjugé

Application: Western Blotting (WB)

Clone: 6-MAP1B

Détail du produit anti-MAP1B anticorps

Épitope: AA 1745-1858

Réactivité croisée: Humain, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse MAP1B aa. 1745-1858

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-MAP1B (ABIN968911)

Ma, Himes, Shea, Fischer: "Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: distinct transport rates of different isoforms." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 6, pp. 2112-20, (2000) (PubMed).

Tögel, Wiche, Propst: "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain." dans: The Journal of cell biology, Vol. 143, Issue 3, pp. 695-707, (1998) (PubMed).

Détails sur MAP1B

Antigène: MAP1B (Microtubule-Associated Protein 1B (MAP1B))

Autre désignation: MAP1B

Sujet: Microtubule-associated proteins (MAPs) play a crucial role in the development and structure of nerve cells. These proteins are important for the assembly and stability of microtubles during neurite outgrowth and for the morphology of neuronal processes, such as dendrites. MAP1B encodes for a single precursor protein that is cleaved to produce a single heavy chain of 280 kDa and a light chain of 32 kDa which become noncovalently associated. Expression levels of MAP1B are reportedly highest in the brain and are modulated during development as reported with gene silencing experiments that implicate MAP1B's role during neuronal differentiation. In addition, MAP1B can be selectively phosphorylated depending on the cell type, subcellular localization and developmental phase. In neurons, MAP1B is expressed as a glycoprotein at the plasma membrane, where it can interact with proteins participating in axonal guiding. MAP1B has been reported to be observable to migrate in a range between 320-340 kDa. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 320-340 kDa

Pathways: Dynamique des Microtubules, Regulation of Cell Size