ABL1 anticorps (AA 577-650)

N° du produit ABIN968942

Il existe 1 publication pour ce produit. L’anticorps anti-ABL1 Monoclonal Souris est utilisé pour la détection de ABL1 dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour ABL1 anticorps (AA 577-650) (ABIN968942)

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABL1 est non-conjugé

Application: ELISA

Clone: 7B11D6

Détail du produit anti-ABL1 anticorps

Épitope: AA 577-650

Fonction: ABL1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ABL1 (ABIN968942)

Lu, Finnis, Xiang, Lee, Markowitz, Okhrimenko, Brodie: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." dans: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).

Détails sur ABL1

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: ABL1

Sujet: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

ID gène: 25

UniProt: P00519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism