Aurora A anticorps

N° du produit ABIN968971

Cet anticorps Souris Monoclonal détecte spécifiquement Aurora A dans WB, ELISA, ICC et FACS. Il présente une réactivité envers Humain, Rat et Singe et a été mentionné dans 2+ publications.

Aperçu rapide pour Aurora A anticorps (ABIN968971)

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 1F8

Détail du produit anti-Aurora A anticorps

Fonction: AURKA Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human AURKA expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Aurora A (ABIN968971)

Veerakumarasivam, Goldstein, Saeb-Parsy, Scott, Warren, Thorne, Mills, Venkitaraman, Neal, Kelly: "AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma." dans: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 22, pp. 3525-33, (2008) (PubMed).

De Luca, Brunetto, Asteriti, Giubettini, Lavia, Guarguaglini: "Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity." dans: Oncogene, Vol. 27, Issue 51, pp. 6539-49, (2008) (PubMed).

Détails sur Aurora A

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Autre désignation: AURKA

Sujet: Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Poids moléculaire: 48 kDa

UniProt: O14965

Pathways: Cycle Cellulaire, Asymmetric Protein Localization