BLK anticorps

N° du produit ABIN968983

Cet anticorps Souris Monoclonal détecte spécifiquement BLK dans ELISA, ICC et FACS. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour BLK anticorps (ABIN968983)

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BLK est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 1E6

Détail du produit anti-BLK anticorps

Fonction: BLK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human BLK expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-BLK (ABIN968983)

Yang, Ng, Zhao, Hirankarn, Lau, Mok, Chan, Wong, Lee, Mok, Wong, Avihingsanon, Lee, Ho, Lee, Wong, Lau: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." dans: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, (2009) (PubMed).

Borowiec, Liew, Thompson, Boonyasrisawat, Hu, Mlynarski, El Khattabi, Kim, Marselli, Rich, Krolewski, Bonner-Weir, Sharma, Sale, Mychaleckyj, Kulkarni, Doria: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, (2009) (PubMed).

Hom, Graham, Modrek, Taylor, Ortmann, Garnier, Lee, Chung, Ferreira, Pant, Ballinger, Kosoy, Demirci, Kamboh, Kao, Tian, Gunnarsson, Bengtsson, Rantapää-Dahlqvist, Petri, Manzi, Seldin, Rönnblom et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." dans: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, (2008) (PubMed).

Détails sur BLK

Antigène: BLK (B Lymphoid Tyrosine Kinase (BLK))

Autre désignation: BLK

Sujet: Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .

Poids moléculaire: 58 kDa

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling