KIT anticorps

N° du produit ABIN968996

Il existe 3+ publications pour ce produit. L’anticorps anti-KIT Monoclonal Souris est utilisé pour la détection de KIT dans des échantillons de Humain. Il a été validé pour ELISA et IHC.

Aperçu rapide pour KIT anticorps (ABIN968996)

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIT est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 8D7

Détail du produit anti-KIT anticorps

Fonction: C-Kit Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of C-kit expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KIT (ABIN968996)

Mojica, Saxena, Starostik, Cheney: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." dans: Histopathology, Vol. 47, Issue 5, pp. 517-22, (2005) (PubMed).

Tong, Liu, Zhang, Xiong, Liu, Zhang: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." dans: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, (2005) (PubMed).

Nakai, Nonomura, Oka, Shiba, Arai, Nakayama, Inoue, Nishimura, Aozasa, Mizutani, Miki, Okuyama: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." dans: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, (2005) (PubMed).

Détails sur KIT

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: C-Kit

Sujet: C-kit (CD117, 145 kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

Poids moléculaire: 145 kDa

ID gène: 3815

UniProt: P10721

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity