PERK anticorps

N° du produit ABIN969093

Cité dans 2 publications. Cet anticorps anti-PERK Monoclonal Souris (Clone 5G5) (ABIN969093) détecte spécifiquement PERK dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PERK anticorps (ABIN969093)

Antigène: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PERK est non-conjugé

Application: ELISA

Clone: 5G5

Détail du produit anti-PERK anticorps

Fonction: EIF2AK3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PERK (ABIN969093)

Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: "Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK." dans: The Journal of biological chemistry, Vol. 283, Issue 25, pp. 17020-9, (2008) (PubMed).

Liang, Yang, Wang, Li, Tang, Chen: "Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha." dans: Human molecular genetics, Vol. 17, Issue 20, pp. 3254-62, (2008) (PubMed).

Détails sur PERK

Antigène: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Autre désignation: EIF2AK3

Sujet: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Poids moléculaire: 125 kDa

ID gène: 9451

UniProt: Q9NZJ5

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response