ELK1 anticorps

N° du produit ABIN969095

L’anticorps Souris Monoclonal anti-ELK1 a été validé pour IHC et ELISA. Il convient pour détecter ELK1 dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour ELK1 anticorps (ABIN969095)

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ELK1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: 3H6D12

Détail du produit anti-ELK1 anticorps

Fonction: ELK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of ELK1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ELK1 (ABIN969095)

Hsieh, Wu, Tsai, Huang, Hsieh, Liu: "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells." dans: Biochemical and biophysical research communications, Vol. 339, Issue 1, pp. 217-25, (2005) (PubMed).

Détails sur ELK1

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Autre désignation: ELK1

Sujet: The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates
transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade.
Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.

UniProt: P19419

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling