ERBB3 anticorps (AA 1175-1275)

N° du produit ABIN969112

Cet anticorps Souris Monoclonal détecte spécifiquement ERBB3 dans IHC et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour ERBB3 anticorps (AA 1175-1275) (ABIN969112)

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERBB3 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: 3F10F6

Détail du produit anti-ERBB3 anticorps

Épitope: AA 1175-1275

Fonction: ERBB3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ERBB3 (ABIN969112)

Sassen, Rochon, Wild, Hartmann, Hofstaedter, Schwarz, Brockhoff: "Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients." dans: Breast cancer research : BCR, Vol. 10, Issue 1, pp. R2, (2008) (PubMed).

Sakai, Yokote, Murakami-Murofushi, Tamura, Saijo, Nishio: "Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway." dans: Cancer science, Vol. 98, Issue 9, pp. 1498-503, (2007) (PubMed).

Détails sur ERBB3

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation: ERBB3

Sujet: ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

UniProt: P21860

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway