FGFR4 anticorps

N° du produit ABIN969139

Cet anticorps Souris Monoclonal détecte spécifiquement FGFR4 dans ELISA et IHC. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour FGFR4 anticorps (ABIN969139)

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGFR4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 4H2B10B2

Détail du produit anti-FGFR4 anticorps

Fonction: FGFR4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of FGFR4 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FGFR4 (ABIN969139)

Ezzat, Zheng, Winer, Asa: "Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications." dans: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2965-75, (2006) (PubMed).

Angelin: "Telling the liver (not) to make bile acids: a new voice from the gut?" dans: Cell metabolism, Vol. 2, Issue 4, pp. 209-10, (2005) (PubMed).

Détails sur FGFR4

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Autre désignation: FGFR4

Sujet: FGFR4 (fibroblast growth factor receptor 4) is part of a family of fibroblast growth factor receptors that mediate the biological functions of specific growth factors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. FGFR4 may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

Poids moléculaire: 88 kDa

ID gène: 2264

UniProt: P22455

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding