Lamin A/C anticorps

N° du produit ABIN969260

L’anticorps Souris Monoclonal anti-Lamin A/C a été validé pour WB, IHC et ELISA. Il convient pour détecter Lamin A/C dans des échantillons de Humain, Souris et Rat. Il y a 1 publication disponible.

Aperçu rapide pour Lamin A/C anticorps (ABIN969260)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4E7

Détail du produit anti-Lamin A/C anticorps

Fonction: LMNA Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human LMNA expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Lamin A/C (ABIN969260)

Carboni, Porcu, Mura, Cocco, Marrosu, Maioli, Solla, Tranquilli, Orrù, Marrosu: "Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement." dans: Muscle & nerve, Vol. 41, Issue 1, pp. 85-91, (2009) (PubMed).

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: LMNA

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Poids moléculaire: 74 kDa

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus