MCM2 anticorps

N° du produit ABIN969280

Cet anticorps Souris Monoclonal détecte spécifiquement MCM2 dans WB, IHC, ELISA et FACS. Il présente une réactivité envers Humain, Souris, Rat et Singe et a été mentionné dans 2+ publications.

Aperçu rapide pour MCM2 anticorps (ABIN969280)

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MCM2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 2B3

Détail du produit anti-MCM2 anticorps

Fonction: MCM2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human MCM2 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MCM2 (ABIN969280)

Chuang, Teixeira, Wohlschlegel, Henze, Yates, Méndez, Reed: "Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry." dans: Molecular cell, Vol. 35, Issue 2, pp. 206-16, (2009) (PubMed).

Liaw, Boyd: "MCM 2 Expression in Basal Cell Carcinomas and Trichoepitheliomas." dans: Journal of cutaneous pathology, Vol. 36, Issue 10, pp. 1121-2, (2009) (PubMed).

Détails sur MCM2

Antigène: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Autre désignation: MCM2

Sujet: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

Poids moléculaire: 125 kDa

ID gène: 4171

UniProt: P49736

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA