MUSK anticorps (AA 24-209)

N° du produit ABIN969299

L’anticorps Souris Monoclonal anti-MUSK a été validé pour ELISA, IHC et ICC. Il convient pour détecter MUSK dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour MUSK anticorps (AA 24-209) (ABIN969299)

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUSK est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 10A4

Détail du produit anti-MUSK anticorps

Épitope: AA 24-209

Fonction: MUSK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MUSK (ABIN969299)

Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." dans: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).

Détails sur MUSK

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Autre désignation: MUSK

Sujet: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Poids moléculaire: 97 kDa

ID gène: 4593

UniProt: O15146

Pathways: Signalisation RTK, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development